Advances In Biochemical Engineering - Biotechnology - Modern

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75 5 Other Applications of SMC . . . . . . . . . . . 3 Use of SMC as Biosensors and for Fast Bioconversion . . . . 80 SMC for Solid Phase Extraction or Fast Sample Clean Up . . . 81 Use of SMC for Solid Phase Synthesis . . . . . . . . 81 6 Conclusions and Perspectives . . . . . . . . . . 82 7 References . . . . . . . . . . . . . . . . 82 1 Introduction The developments in molecular and cell biology in the last quarter of the 20th century led to new technologies for the production of complex biomolecules which have the potential to assist in human health care in the areas of diagnostics, prevention and treatment of diseases.

81 Use of SMC for Solid Phase Synthesis . . . . . . . . 81 6 Conclusions and Perspectives . . . . . . . . . . 82 7 References . . . . . . . . . . . . . . . . 82 1 Introduction The developments in molecular and cell biology in the last quarter of the 20th century led to new technologies for the production of complex biomolecules which have the potential to assist in human health care in the areas of diagnostics, prevention and treatment of diseases. One of the most important and at the same time most expensive step in their production is the isolation and cleaning (down-stream processing) of the target biomolecule(s).

As a result, the pressure drop along the column is one-third to one-fifth of that on columns packed with 3- or 5-mm beads. The resulting pressure drop is therefore much lower, allowing operation at higher flow rates while the optimized separation efficiencies are comparable to silica columns packed with 4 mm particles [39]. Scaled up units intended for semi-preparative purposes were developed as well and were first reported by Schulte et al. [40]. 014 mm and this allows even higher flow rates to be used then in case of the analytical ones.

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