Alcohol and Its Biomarkers: Clinical Aspects and Laboratory by Amitava Dasgupta

By Amitava Dasgupta

Alcohol and Its Biomarkers: medical features and Laboratory Determination is a concise consultant to all presently recognized alcohol biomarkers, their medical program, and the laboratory equipment used to notice them. Pathologists can use this source to appreciate the restrictions and price components linked to each one process for making a choice on yes alcohol biomarkers. moreover, interferences in those determinations are mentioned, in order that clinicians can comprehend the reasons of falsely increased biomarkers and pathologists and laboratory scientists can most likely do away with them. The ebook specializes in the analytical tools used to become aware of alcohol in blood and urine, the constraints of alcohol selection utilizing enzymatic tools, and the variations among medical and forensic alcohol size. Chapters additionally disguise state-of-the-art alcohol biomarkers for strength use.

  • Focuses at the analytical tools used for detecting alcohol in blood and urine besides the pitfalls and boundaries of alcohol choice utilizing enzymatic methods
  • Explains the variation among medical and forensic alcohol measurement
  • Includes a quick evaluation of some great benefits of eating alcohol carefully and the dangers of heavy drinking

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Additional info for Alcohol and Its Biomarkers: Clinical Aspects and Laboratory Determination

Sample text

This enzyme has a higher Michaelis constant (in contrast to most ADH) and plays an important role in ethanol metabolism by the liver, especially at high blood alcohol concentration, accounting for approximately 30% of ethanol metabolism. The ADH5 gene encodes the chi (χ) subunit, producing class III ADH, which is usually a homodimer. This enzyme is a ubiquitously expressed formaldehyde dehydrogenase with a very low affinity for ethanol. The major function of this enzyme is to oxidize formaldehyde to formic acid and to terminate nitric oxide signaling.

Observed that both drinking while depressed and episodic heavy drinking were associated with self-reported suicide attempts in adolescents [102]. Swahn et al. reported that in a high-risk school district in the United States, 35% of seventh graders reported alcohol abuse starting at age 13 years or younger. Preteen alcohol users were more involved in violent behavior than were nondrinkers. Early alcohol use was also associated with higher risk of suicide attempts among these adolescents [103]. 9 Alcohol Abuse and Violent Behavior/Homicide Many investigators have reported a close link between violent behavior, homicide, and alcohol intoxication.

Women drinkers who consumed two drinks or more in a session also showed all-cause higher mortality than moderate drinkers (one or fewer drinks per day). Among men, both quantity and frequency of drinking were significantly associated with mortality from cardiovascular disease, cancer, and other causes; among women, the quantity of alcohol was more important, and those who drank more than moderately showed a higher risk of mortality from cancer than did men [98]. The London-based Whitehall II cohort study, which involved 10,308 government employees aged 35À55 years with an 11-year follow-up, also concluded that optimal drinking is once or twice per week to daily consumption of one drink or fewer.

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